RT Journal Article
T1 Roughness of retinal layers in Alzheimer’s disease
A1 Jáñez García, Lucía
A1 Bachtoula González, Omar
A1 García Martín, Elena Salobrar
A1 Hoz Montañana, María Rosa De
A1 Ramírez Sebastián, Ana Isabel
A1 Gil Gregorio, Pedro
A1 Ramírez Sebastián, José Manuel
A1 Jáñez Escalada, Luis
AB There is growing evidence that thinned retinal regions are interspersed with thickened regions in all retinal layers of patients with Alzheimer’s disease (AD), causing roughness to appear on layer thickness maps. The hypothesis is that roughness of retinal layers, assessed by the fractal dimension (FD) of their thickness maps, is an early biomarker of AD. Ten retinal layers have been studied in macular volumes of optical coherence tomography from 24 healthy volunteers and 19 patients with mild AD (Mini-Mental State Examination 23.42 ± 3.11). Results show that FD of retinal layers is greater in the AD group, the differences being statistically significant (p < 0.05). Correlation of layer FD with cognitive score, visual acuity and age reach statistical significance at 7 layers. Nearly all (44 out of 45) FD correlations among layers are positive and half of them reached statistical significance (p < 0.05). Factor analysis unveiled two independent factors identified as the dysregulation of the choroidal vascular network and the retinal inflammatory process. Conclusions: surface roughness is a holistic feature of retinal layers that can be assessed by the FD of their thickness maps and it is an early biomarker of AD.
PB Nature publishing group
SN 2045-2322
YR 2021
FD 2021-06-03
LK https://hdl.handle.net/20.500.14352/8304
UL https://hdl.handle.net/20.500.14352/8304
LA eng
NO Jáñez García, L., Bachtoula González, O., García Martín, E. S. et al. «Roughness of Retinal Layers in Alzheimer’s Disease». Scientific Reports, vol. 11, n.o 1, junio de 2021, p. 11804. DOI.org (Crossref), https://doi.org/10.1038/s41598-021-91097-3.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
NO Fondo Europeo de Desarrollo Regional
DS Docta Complutense
RD 8 abr 2025