RT Journal Article
T1 Demographic and Clinical Characteristics of Hospitalized Patients with Type 2 Diabetes Mellitus and Comorbid Parkinson’s Disease in Spain: A Nationwide Observational Study (2017–2023)
A1 Gómez Mayordomo, Víctor
A1 Jiménez García, Rodrigo
A1 Zamorano León, José Javier
A1 Carabantes Alarcón, David
A1 Bodas Pinedo, Andrés
A1 Hernández Barrera, Valentín
A1 López De Andrés, Ana Isabel
A1 Cuadrado Corrales, María Natividad
AB Background/Objectives: Type 2 diabetes mellitus (T2DM) and Parkinson’s disease (PD) are two highly prevalent chronic conditions that often coexist in older adults. Their interaction may influence clinical outcomes, particularly during external stressors such as the COVID-19 pandemic. This study aimed to assess the prevalence and temporal trends of PD among hospitalized patients with T2DM in Spain (2017–2023), evaluate sex-based differences in clinical characteristics and outcomes, examine the impact of the COVID-19 pandemic, and identify predictors of PD diagnosis and in-hospital mortality (IHM). Methods: We conducted a retrospective, nationwide study using the Spanish National Hospital Discharge Database (RAE-CMBD). Adults aged ≥40 years hospitalized with T2DM were included. PD cases were identified using ICD-10 codes. Joinpoint regression assessed temporal trends, and multivariable logistic regression identified factors associated with PD and IHM. Results: Among 5.1 million T2DM-related hospitalizations, 107,931 (2.41%) involved PD. PD prevalence increased over time, particularly among women. Men accounted for most PD cases and were younger than their female counterparts. Depression and anxiety were more frequent in women and associated with PD in both sexes. IHM peaked at 14.6% in 2020, coinciding with the COVID-19 outbreak. Predictors of IHM included older age, higher comorbidity burden, dementia, and COVID-19 diagnosis. Conclusions: The coexistence of PD and T2DM in hospitalized patients is associated with clinical complexity and increased mortality. Personalized, multidisciplinary care is essential to address sex-specific patterns, psychiatric comorbidities, and vulnerability to systemic stressors.
PB MDPI
SN 2077-0383
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/122383
UL https://hdl.handle.net/20.500.14352/122383
LA eng
NO Gómez-Mayordomo, V., Jiménez-García, R., Zamorano-León, J. J., Carabantes-Alarcón, D., Bodas-Pinedo, A., Hernández-Barrera, V., López-de-Andrés, A., & Cuadrado-Corrales, N. (2025). Demographic and Clinical Characteristics of Hospitalized Patients with Type 2 Diabetes Mellitus and Comorbid Parkinson’s Disease in Spain: A Nationwide Observational Study (2017–2023). Journal of Clinical Medicine, 14(13), 4679. https://doi.org/10.3390/jcm14134679
NO Fondo Europeo de Desarrollo Regional (FEDER, “Una manera de hacer Europa”)V PRICIT (Regional Programme of Research and Technological InnovationGrupo de Investigación en Epidemiología de las Enfermedades Crónicas de Alta Prevalencia en EspañaGrupo de Investigación en Biomedicina Predictiva e Investigación Traslacional en las Enfermedades Respiratorias, Cardiovasculares y Metabólicas
NO Instituto de Salud Carlos III
NO European Commission
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
NO Hospital Clínico San Carlos
DS Docta Complutense
RD 18 mar 2026