RT Journal Article
T1 Multienzymatic Processes Involving Baeyer–Villiger Monooxygenases
A1 Gonzalo, Gonzalo de
A1 Alcántara León, Andrés Rafael
AB Baeyer–Villiger monooxygenases (BVMOs) are flavin-dependent oxidative enzymes capable of catalyzing the insertion of an oxygen atom between a carbonylic Csp2 and the Csp3 at the alpha position, therefore transforming linear and cyclic ketones into esters and lactones. These enzymes are dependent on nicotinamides (NAD(P)H) for the flavin reduction and subsequent reaction with molecular oxygen. BVMOs can be included in cascade reactions, coupled to other redox enzymes, such as alcohol dehydrogenases (ADHs) or ene-reductases (EREDs), so that the direct conversion of alcohols or α,β-unsaturated carbonylic compounds to the corresponding esters can be achieved. In the present review, the different synthetic methodologies that have been performed by employing multienzymatic strategies with BVMOs combining whole cells or isolated enzymes, through sequential or parallel methods, are described, with the aim of highlighting the advantages of performing multienzymatic systems, and show the recent advances for overcoming the drawbacks of using BVMOs in these techniques.
PB MDPI
SN 2073-4344
YR 2021
FD 2021-05-08
LK https://hdl.handle.net/20.500.14352/7435
UL https://hdl.handle.net/20.500.14352/7435
LA eng
NO Spanish Ministry of Science and Innovation
NO Banco de Santander-Complutense Research Projects
DS Docta Complutense
RD 8 abr 2025