%0 Journal Article
%A Romero Martínez, Manuel Alejandro
%A Egea, Javier
%A González-Muñoz, Gema 
%A Martín De Saavedra Álvarez De Uribarri, María Dolores
%A Barrio, Laura del
%A Rodríguez-Franco, María Isabel
%A Conde, Santiago
%A López, Manuela 
%A Villarroya, Mercedes
%A Ríos, Cristóbal de los
%T ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease
%D 2014
%@ 1948-7193
%U https://hdl.handle.net/20.500.14352/96908
%X The neuroprotective profile of the dibenzothiadiazepine ITH12410/SC058 (2-chloro-5,6-dihydro-5,6-diacetyldibenzo[b,f][1,4,5]thiadiazepine) against several neurotoxicity models related to neurodegenerative diseases is herein described. ITH12410/SC058 protected SH-SY5Y cells against the loss of cell viability elicited by amyloid beta peptide and okadaic acid, a selective inhibitor of phosphoprotein phosphatase 2A that induces neurofibrillary tangle formation. Furthermore, ITH12410/SC058 is neuroprotective against several in vitro models of oxidative stress, that is, H2O2 exposure or incubation with rotenone plus oligomycin A in SH-SY5Y cells, and oxygen and glucose deprivation followed by reoxygenation in rat hippocampal slices. By contrast, ITH12410/SC058 was unable to significantly protect SH-SY5Y neuroblastoma cells against the toxicity elicited by Ca2+ overload. Our results confirm the hypothesis that the dibenzothiadiazepine ITH12410/SC058 features its neuroprotective actions in a multitarget fashion, and is a promising drug for the treatment of neurodegenerative diseases
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