RT Journal Article
T1 ITH12410/SC058: A New Neuroprotective Compound with Potential in the Treatment of Alzheimer’s Disease
A1 Romero Martínez, Manuel Alejandro
A1 Egea, Javier
A1 González-Muñoz, Gema
A1 Martín De Saavedra Álvarez De Uribarri, María Dolores
A1 Barrio, Laura del
A1 Rodríguez-Franco, María Isabel
A1 Conde, Santiago
A1 López, Manuela
A1 Villarroya, Mercedes
A1 Ríos, Cristóbal de los
AB The neuroprotective profile of the dibenzothiadiazepine ITH12410/SC058 (2-chloro-5,6-dihydro-5,6-diacetyldibenzo[b,f][1,4,5]thiadiazepine) against several neurotoxicity models related to neurodegenerative diseases is herein described. ITH12410/SC058 protected SH-SY5Y cells against the loss of cell viability elicited by amyloid beta peptide and okadaic acid, a selective inhibitor of phosphoprotein phosphatase 2A that induces neurofibrillary tangle formation. Furthermore, ITH12410/SC058 is neuroprotective against several in vitro models of oxidative stress, that is, H2O2 exposure or incubation with rotenone plus oligomycin A in SH-SY5Y cells, and oxygen and glucose deprivation followed by reoxygenation in rat hippocampal slices. By contrast, ITH12410/SC058 was unable to significantly protect SH-SY5Y neuroblastoma cells against the toxicity elicited by Ca2+ overload. Our results confirm the hypothesis that the dibenzothiadiazepine ITH12410/SC058 features its neuroprotective actions in a multitarget fashion, and is a promising drug for the treatment of neurodegenerative diseases
SN 1948-7193
YR 2014
FD 2014
LK https://hdl.handle.net/20.500.14352/96908
UL https://hdl.handle.net/20.500.14352/96908
LA eng
NO Instituto de Salud Carlos III
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 17 abr 2025