RT Journal Article
T1 Microwave-driven synthesis of bisphosphonate nanoparticles allows in vivo visualisation of atherosclerotic plaque
A1 Pellico, J.
A1 Lechuga Vieco, A. V,
A1 Benito, M.
A1 García Segura, Juan Manuel
A1 Fúster, V.
A1 Ruiz Cabello, J.
A1 Herranz, F.
AB A fast and reproducible microwave-driven process has allowed us to synthesise neridronate-functionalised nanoparticles. Contrary to tradition, the phosphate groups decorate the outside layer of the particles providing Ca2+ binding properties in vitro and selective accumulation in vivo in the atheroma plaque. In vivo and ex vivo detection by T2-weighted MRI is demonstrated and validated by histology. The accumulation in the plaque takes place in less than one hour following the intravenous injection, which is particularly suitable for clinical applications.
PB Royal Society of Chemistry
SN 2046-2069
YR 2015
FD 2015-01-09
LK https://hdl.handle.net/20.500.14352/35502
UL https://hdl.handle.net/20.500.14352/35502
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Fundació La Marató de TV3 (España)
DS Docta Complutense
RD 1 may 2024