RT Journal Article
T1 Neuropsychological, clinical and environmental predictors of severe mental disorders in offspring of patients with schizophrenia
A1 Moreno Ruiz, María del Carmen
A1 Sánchez-Gutiérrez T, 
A1 Rodríguez Toscano, Elisa
A1 Llorente C, 
A1 de la Serna E, 
A1 Sugranyes G, 
A1 Romero S, 
A1 Calvo Calvo, Ana Belén
A1 Baeza I, 
A1 Sánchez-Gistau V, 
A1 Espliego A, 
A1 Castro-Fornieles J, 
A1 Moreno Pardillo, Dolores María
AB Offspring of individuals with schizophrenia (SZCOff) are at an increased risk for this disorder. Neuropsychological decline is a core feature of the disorder and researchers have reported increasing impairments in cognition during the prodromal phase in high-risk adolescents. Additionally, factors like the presence of prodromal symptoms or specific behavioral patterns could predict, together with neurocognitive functioning, the risk of conversion to severe mental disorders in SCZOff. This study aims to compare the neuropsychological functioning of a sample of 41 SCZOff children and adolescents and 105 community control offspring (CCOff) and to develop a prediction model to examine whether neuropsychological functioning, clinical and behavioral factors predict subsequent risk of severe mental disorders. We collected demographic, clinical and neuropsychological data. We found significant differences between groups in working memory, speed of processing, verbal memory and learning, visual memory and intelligence quotient (IQ). The socioeconomic status, verbal memory, working memory and positive prodromal symptoms predicted a significant proportion of the dependent variable variance. In conclusion, SCZOff showed neurocognitive impairments in several neuropsychological domains compared to CCOff. Neuropsychological functioning, environmental factors and positive prodromal symptoms could predict the risk of onset of severe mental disorders in SCZOff.
PB Springer
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/115536
UL https://hdl.handle.net/20.500.14352/115536
LA eng
NO Sánchez-Gutiérrez T, Rodríguez-Toscano E, Llorente C, de la Serna E, Moreno C, Sugranyes G, Romero S, Calvo A, Baeza I, Sánchez-Gistau V, Espliego A, Castro-Fornieles J, Moreno D. Neuropsychological, clinical and environmental predictors of severe mental disorders in offspring of patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2020 Sep;270(6):739-748.
NO Spanish Ministry of Economy, Industry and Competitiveness
NO Carlos III Health Institute [PI070066, PI1100683, PI15/00810]
NO Catalonia Government [DIUE 2014SGR489]
NO ERDF Funds from the European Commission, “A way of making Europe”
NO CIBERSAM
NO Madrid Regional Government [S2010/BMD-2422 AGES]
NO European Union Structural Funds and European Union Seventh Framework Program and H2020 Program
NO Alicia Koplowitz Foundation
NO Mutua Madrileña Foundation
DS Docta Complutense
RD 5 abr 2025