RT Journal Article
T1 Large scale production of biocompatible magnetite nanocrystals with high saturation magnetization values through green aqueous synthesis
A1 Marciello, Marzia
A1 Connord, Vincent
A1 Veintemillas-Verdaguer, Sabino
A1 Andrés Vergés, Manuel
A1 Carrey, Julian
A1 Respaud, Marc
A1 Serna Pereda, Carlos J.
A1 Puerto Morales, María Del
AB In this work, a straightforward aqueous synthesis for mass production (up to 20 g) of uniform and crystalline magnetite nanoparticles with core sizes between 20 and 30 nm, which are the optimum nanoparticle core sizes for hyperthermia applications, is proposed. Magnetic and heating properties have been analyzed showing very high saturation magnetization and magnetic heating values. To stabilize the naked magnetite nanocrystals at physiological pH and increase their circulation time in blood, they have been covalently coated with carboxymethyl dextran, a biocompatible polymer. The influence of this superficial modification on the magnetic and heating properties has been studied showing that these biocompatible magnetic nanocrystals maintain high saturation magnetization values, good colloidal stability and hyperthermia properties in the presence of the polymeric external layer. These particles, suitably functionalized, could be used to selectively kill cancer cells under a moderate alternating magnetic field (44 mT and 70 kHz)
SN 2050-750X
YR 2013
FD 2013-09-11
LK https://hdl.handle.net/20.500.14352/100812
UL https://hdl.handle.net/20.500.14352/100812
LA eng
NO Marciello M, Connord V, Veintemillas-Verdaguer S, Vergés MA, Carrey J, Respaud M, et al. Large scale production of biocompatible magnetite nanocrystals with high saturation magnetization values through green aqueous synthesis. J Mater Chem B 2013;1:5995. https://doi.org/10.1039/c3tb20949k
NO Ministerio de Economía y Competitividad (España)
NO Comunidad de Madrid
NO EU-FP7 MULTIFUN project
DS Docta Complutense
RD 8 abr 2025