RT Journal Article
T1 Nano and microtechnologies for ophthalmic administration. An overview
A1 Herrero Vanrell, María Del Rocío
A1 Vicario De La Torre, Marta
A1 Andrés-Guerrero, Vanessa
A1 Barbosa-Alfaro, Deyanira
A1 Molina Martínez, Irene Teresa
A1 Bravo Osuna, Irene
AB Ocular drug delivery is one of the most challenging fields of pharmaceutical research. They are generally employed to overcome the static (different layers of cornea, sclera, and retina including blood aqueous and blood-retinal barriers) and dynamic barriers (choroidal and conjunctival blood flow, lymphatic clearance, and tear dilution) of the eye. Ophthalmic formulations must be sterile, and the biomaterials used in the preparation of pharmaceutical systems completely compatible and extremely well tolerated by ocular tissues. The location of the target tissue in the eye will determine the route of administration. Ophthalmic administration systems are intended for topical, intraocular and periocular administration. In this review we describe the main pharmaceutical nano- and microsystems currently under study to administrate drugs in the eye, covering microparticles, nanoparticles, liposomes, microemulsions, niosomes and dendrimers. We have performed the corresponding revision of the published scientific literature always emphasizing the technological aspects. The review discusses also the biomaterials used in the preparation of the nano and microsystems of ophthalmic drug delivery, fabrication techniques, therapeutic significances, and future possibilities in the field.
PB Elsevier
SN 1773-2247
YR 2013
FD 2013
LK https://hdl.handle.net/20.500.14352/34092
UL https://hdl.handle.net/20.500.14352/34092
LA eng
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad Complutense de Madrid
NO Ministerio de Educación, Formación Profesional y Deportes (España)
DS Docta Complutense
RD 7 oct 2024