RT Journal Article
T1 Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns
A1 Nieto Barbero, María Asunción
A1 Rodriguez Nieto, Maria J.
A1 Sanchez Pernaute, Olga
A1 Romero Bueno, Fredeswinda
A1 Leon, Leticia
A1 Vadillo, Cristina
A1 Freites Nuñez, Dalifer D.
A1 Jover Jover, Juan Ángel
A1 Álvarez-Sala Walther, José Luis
A1 Abasolo, Lydia
AB BackgroundTo assess mortality rate (MR) and standardized mortality rate (SMR) of rheumatoid arthritis-related interstitial lung disease (RA-ILD) patients and to evaluate the role of radiographic patterns in mortality.MethodsA longitudinal multicentric study was conducted in RA-ILD patients from 2005 to 2015 and followed-up until October 2018 in Madrid. Patients were included in the Neumologia-Reumatología y Enfermedades Autoinmunes Registry, from diagnosis of ILD. The main outcome was all-cause mortality. The radiographic pattern at baseline [usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), or others] was the independent variable. Covariables included sociodemographic and clinical data. Survival techniques were used to estimate MR, expressed per 1000 persons-year with their 95% confidence intervals [CI]. Cox multiple regression model was run to examine the influence of radiographic patterns on survival. SMR [CI] was calculated comparing MR obtained with MR expected in the general population of Madrid by indirect age-gender standardization.Results47 patients were included with a follow-up 242 patients-year. There were 16 (34%) deaths, and most frequent causes were acute ILD exacerbation and pneumonia. MR was 64.3 [39.4–104.9], and 50% of the patients died at 8.3 years from ILD diagnosis. After adjusting for confounders, (UIP compared to NSIP was associated with higher mortality risk. The overall SMR was 2.57 [1.4–4.17]. Women of 60–75 years of age were the group with the highest SMR.ConclusionsRA-ILD is associated with an excess of mortality compared to general population. Our results support that UIP increases the risk of mortality in RA-ILD, regardless other factors.
PB Springer Nature
SN 1471-2466
YR 2021
FD 2021-06-30
LK https://hdl.handle.net/20.500.14352/134784
UL https://hdl.handle.net/20.500.14352/134784
LA eng
NO Nieto MA, Rodriguez-Nieto MJ, Sanchez-Pernaute O, Romero-Bueno F, Leon L, Vadillo C, et al. Mortality rate in rheumatoid arthritis-related interstitial lung disease: the role of radiographic patterns. BMC Pulm Med 2021;21:205. https://doi.org/10.1186/s12890-021-01569-5.
DS Docta Complutense
RD 30 abr 2026