RT Journal Article
T1 Fetal development and growth of the fissula ante fenestram in the human ear
A1 Rodríguez Vázquez, José Francisco
A1 Iglesias Moreno, María Cruz
A1 Poch Pérez-Botija, Adriana
A1 Murakami, Gen
A1 Abe, Hiroshi
A1 Honkura, Yohei
AB Since the fissula ante fenestram (FAF) is considered as a focus of otosclerotic lesion and a route of perilymph leakage, there are few description of prenatal development of the cartilaginous canal passing though the cochlear wall. We examined the sagittal and frontal histological sections of the ear from 32 human fetuses at 8–37 weeks of gestational age. At 8–12 weeks, in the immediately anterior side of a connection between the cochlear and canalicular parts of the otic capsule cartilage, the FAF appeared as a tear of a cartilage between the basal and second turns of the cochlea. The tear became a slit opening to the scala vestibuli. At 13–15 weeks, the FAF, less than 1.2 mm in length, had the anterosuperior and postero-inferior apertures: the former was near the geniculate ganglion and became closed after 15 weeks, while the latter approached the oval window. Third trimester fetuses, the FAF, 1.5–2.0 mm in length, consistently carried a single, postero-inferior aperture extending along the anterior margin of the oval window and it contained no definite epithelium and vessel. Although it was endochondral ossification, there was no clear zonation in cartilage cells of the FAF. A mechanical stress during three-dimensional coiling of the cochlear ducts seemed to provide the FAF. After the FAF was established, the stapes footplate might use a part of the inferior aperture for the syndesmosis. A specific ossification was seen in the FAF, but it might rarely cause the pathological syndesmosis.
PB Wiley
SN 1932-8486
YR 2021
FD 2021-07-09
LK https://hdl.handle.net/20.500.14352/4720
UL https://hdl.handle.net/20.500.14352/4720
LA eng
NO Rodríguez Vázquez, J. F., Iglesias Moreno, M. C., Poch Pérez-Botija, A. et al. «Fetal Development and Growth of the Fissula Ante Fenestram in the Human Ear». The Anatomical Record, vol. 305, n.o 2, febrero de 2022, pp. 424-35. DOI.org (Crossref), https://doi.org/10.1002/ar.24711.
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO JSPS KAKENHI
DS Docta Complutense
RD 8 abr 2025