RT Journal Article
T1 Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis
A1 Roy Vallejo, Emilia
A1 Fernández De Córdoba-Oñate, Sara
A1 Delgado-Wicke, Pablo
A1 Triguero-Martínez, Ana
A1 Montes, Nuria
A1 Carracedo-Rodríguez, Rosa
A1 Zurita-Cruz, Nelly
A1 Marcos-Jiménez, Ana
A1 Lamana Domínguez, Amalia
A1 Galván-Román, José María
A1 Villapalos García, Gonzalo
A1 Zubiaur, Pablo
A1 Ciudad, Marianela
A1 Rabes, Laura
A1 Rodríguez, Carlos
A1 Villa, Almudena
A1 Álvarez Rodríguez, Jesús
A1 Marcos, Celeste
A1 Hernando, Julia
A1 Díaz-Fernández, Paula
A1 Abad, Francisco
A1 Santos, Ignacio de los
A1 Sanz Sanz, Marta
A1 Rodríguez Serrano, Diego
A1 García-Vicuña, Rosario
A1 Suárez Fernández, Carmen
A1 Pérez Gomáriz, Rosa María
A1 Muñoz-Calleja, Cecilia
A1 Fernández-Ruiz, Elena
A1 González-Álvaro, Isidoro
A1 Cardeñoso, Laura
AB Introduction: SARS-CoV-2 viral load has been related to COVID-19 severity. The main aim of this study was to evaluate the relationship between SARS-CoV-2 viremia and SNPs in genes previously studied by our group as predictors of COVID-19 severity. Materials and methods: Retrospective observational study including 340 patients hospitalized for COVID-19 in the University Hospital La Princesa between March 2020 and December 2021, with at least one viremia determination. Positive viremia was considered when viral load was above the quantifiable threshold (20 copies/ml). A total of 38 SNPs were genotyped. To study their association with viremia a multivariate logistic regression was performed. Results: The mean age of the studied population was 64.5  years (SD 16.6), 60.9% patients were male and 79.4% white non-Hispanic. Only 126 patients (37.1%) had at least one positive viremia. After adjustment by confounders, the presence of the minor alleles of rs2071746 (HMOX1; T/T genotype OR 9.9 p
PB Frontiers
SN 2296-858X
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/94195
UL https://hdl.handle.net/20.500.14352/94195
LA eng
NO Roy-Vallejo, Emilia, et al. «Occurrence of SARS-CoV-2 viremia is associated with genetic variants of genes related to COVID-19 pathogenesis». Frontiers in Medicine, vol. 10, septiembre de 2023, p. 1215246. https://doi.org/10.3389/fmed.2023.1215246.
NO This study was funded with grants: “Fondos Supera COVID19” by Banco Santander and CRUE to CSF, RG-V, CM-C, and RPG; RD21/0002/0027, PI18/0371 and PI21/00526 to IG-Á, and PI19/00096 to EF-R from Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) and co-funded by European regional development fund (ERDF) “A way to make Europe”; and co-financed by the Community of Madrid through the Covid 2019 Aid. The work of ER-V has been funded by a Rio-Hortega grant CM19/00149 from the Ministerio de Economía y Competitividad (Instituto de Salud Carlos III) and co-funded by The European Regional Development Fund (ERDF) “A way to make Europe.” GVG is co-financed by Instituto de Salud Carlos III (ISCIII) and the European Social Fund (PFIS predoctoral grant, number FI20/00090). PZ is financed by Universidad Autónoma de Madrid, Margarita Salas contract, grants for the requalification of the Spanish university system.
NO Comunidad de Madrid
NO Ministerio de Economía y Competitividad (España)
NO European Commission
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 12 abr 2025