RT Journal Article
T1 Effect of the use of platelet concentrates on new bone formation in alveolar ridge preservation: a systematic review, meta‐analysis, and trial sequential analysis
A1 Vito Carlo, Alberto Caponio
A1 Baca‐González, Laura
A1 González Serrano, José
A1 Torres García Denche, Jesús
A1 López-Pintor Muñoz, Rosa María
AB Objectives: To investigate the histomorphometric changes occurring in alveolar ridge preservation (ARP) based on the use of different plasma concentrates (PCs) in randomized clinical trials (RCT). There is controversy whether the placement of PCs in ARP is effective in the formation of new bone.Materials and methods: A systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICO question: In patients undergoing tooth extraction followed by ARP, do PCs alone in the post-extraction socket in comparison with spontaneous healing improve new vital bone formation percentage in histomorphometric analysis after more than 10 weeks? The risk of bias was assessed and a meta-analysis was conducted.Results: Of 3809 results, 8 studies were considered suitable for inclusion. A total of 255 teeth were extracted in 250 patients. Regarding the PCs used, ARP was performed with platelet- and leukocyte-rich fibrin (L-PRF) in 120 sockets, and with pure platelet-rich plasma (P-PRP) in 31 sockets and 104 sockets were controlled. PCs improved new bone formation in ARP with respect to the spontaneous healing group (SMD = 1.77, 95%C.I. = 1.47-2.06, p-value < 000.1). There were no differences between the different PCs (L-PRF and P-PRP).Conclusion: The results of this meta-analysis support the efficacy of the use of PCs in new bone formation in ARP. With respect to the different types of PCs studied, no differences were observed.Clinical relevance: When planning implant surgery after tooth extraction, treatment with PCs should be considered for ARP. Any PC increases new bone formation compared to spontaneous healing.
PB Springer Nature
SN 1432-6981
YR 2023
FD 2023-07-13
LK https://hdl.handle.net/20.500.14352/117884
UL https://hdl.handle.net/20.500.14352/117884
LA eng
NO Caponio VCA, Baca-González L, González-Serrano J, Torres J, López-Pintor RM. Effect of the use of platelet concentrates on new bone formation in alveolar ridge preservation: a systematic review, meta-analysis, and trial sequential analysis. Clin Oral Investig. 2023 Aug;27(8):4131-4146. doi: 10.1007/s00784-023-05126-8
DS Docta Complutense
RD 8 abr 2025