RT Journal Article
T1 New mechanisms involved in the development of cardiovascular disease in chronic kidney disease
A1 Figuer, Andrea
A1 Alique, Matilde
A1 Valera Arévalo, Gemma
A1 Serroukh, Nadia
A1 Ceprían, Noemí
A1 De Sequera Ortiz, Patricia
A1 Morales Ruiz, Enrique
A1 Carracedo Añón, Julia María
A1 Ramírez, Rafael
A1 Bodega, Guillermo
AB Chronic kidney disease (CKD) is a pathology with a high worldwide incidence and an upward trend affecting the elderly. When CKD is very advanced, the use of renal replacement therapies is required to prolong its life (dialysis or kidney transplantation). Although dialysis improves many complications of CKD, the disease does not reverse completely. These patients present an increase in oxidative stress, chronic inflammation and the release of extracellular vesicles (EVs), which cause endothelial damage and the development of different cardiovascular diseases (CVD). CKD patients develop premature diseases associated with advanced age, such as CVD. EVs play an essential role in developing CVD in patients with CKD since their number increases in plasma and their content is modified. The EVs of patients with CKD cause endothelial dysfunction, senescence and vascular calcification. In addition, miRNAs free or transported in EVs together with other components carried in these EVs promote endothelial dysfunction, thrombotic and vascular calcification in CKD, among other effects. This review describes the classic factors and focuses on the role of new mechanisms involved in the development of CVD associated with CKD, emphasizing the role of EVs in the development of cardiovascular pathologies in the context of CKD. Moreover, the review summarized the EVs’ role as diagnostic and therapeutic tools, acting on EV release or content to avoid the development of CVD in CKD patients
PB Elsevier
SN 0211-6995
YR 2023
FD 2023-05-01
LK https://hdl.handle.net/20.500.14352/122749
UL https://hdl.handle.net/20.500.14352/122749
LA eng
NO Figuer, A., Alique, M., Valera, G., Serroukh, N., Ceprían, N., de Sequera, P., Morales, E., Carracedo, J., Ramírez, R., & Bodega, G. (2023). New mechanisms involved in the development of cardiovascular disease in chronic kidney disease. Nefrología (English Edition), 43(1), 63-80. https://doi.org/10.1016/j.nefroe.2023.05.014
NO Funding: Supported by Instituto de Salud Carlos III, projects PI17/01029, PI19/00240, PI20/01321 (co-funded by EU ERDF/ESF “Una manera de hacer Europa”/“El FSE invierte en tu futuro”), Sociedad Española de Nefrología (Senefro Foundation Project).Becas individuales: AF – predoctoral fellow, Instituto de Salud Carlos III (FI20/00018). GV – grant from Comunidad de Madrid and the European Social Fund (PEJ-2020-AI/BMD-18141). NS – grant from Instituto de Investigación Sanitaria Hospital 12 de Octubre (i+12).
NO Instituto de Salud Carlos III
NO Unión Europea
NO Sociedad Española de Nefrología
NO Comunidad de Madrid
NO Instituto de Investigación Sanitaria Hospital 12 de Octubre
DS Docta Complutense
RD 25 feb 2026