RT Journal Article
T1 Superparamagnetic iron oxide nanoparticles decorated mesoporous silica nanosystem for combined antibiofilm therapy
A1 Álvarez Corchado, Elena
A1 Estévez Amado, Manuel
A1 Gallo Cordova, Álvaro
A1 González Ortiz, Blanca
A1 Castillo, Rafael R.
A1 Morales, María del Puerto
A1 Colilla Nieto, Montserrat
A1 Izquierdo Barba, Isabel
A1 Vallet Regí, María Dulce Nombre
AB A crucial challenge to face in the treatment of biofilm-associated infection is the ability of bacteria to develop resistance to traditional antimicrobial therapies based on the administration of antibiotics alone. This study aims to apply magnetic hyperthermia together with controlled antibiotic delivery from a unique magnetic-responsive nanocarrier for a combination therapy against biofilm. The design of the nanosystem is based on antibiotic-loaded mesoporous silica nanoparticles (MSNs) externally functionalized with a thermo-responsive polymer capping layer, and decorated in the outermost surface with superparamagnetic iron oxide nanoparticles (SPIONs). The SPIONs are able to generate heat upon application of an alternating magnetic field (AMF), reaching the temperature needed to induce a change in the polymer conformation from linear to globular, therefore triggering pore uncapping and the antibiotic cargo release. The microbiological assays indicated that exposure of E. coli biofilms to 200 µg/mL of the nanosystem and the application of an AMF (202 kHz, 30 mT) decreased the number of viable bacteria by 4 log10 units compared with the control. The results of the present study show that combined hyperthermia and antibiotic treatment is a promising approach for the effective management of biofilm-associated infections.
PB MDPI
SN 1999-4923
YR 2023
FD 2023-02-07
LK https://hdl.handle.net/20.500.14352/72380
UL https://hdl.handle.net/20.500.14352/72380
LA eng
NO Horizon 2020
NO European Research Council
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 10 jun 2025