RT Journal Article
T1 Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration
A1 Bari, Alessandra
A1 Bloise, Nora
A1 Fiorilli, Sonia
A1 Novajra, Giorgia
A1 Vallet Regí, María Dulce Nombre
A1 Brunni, Giovanna
A1 Torres Pardo, Almudena
A1 González Calvet, J. M.
A1 Visai, Libia
A1 Vitale-Brovarone, Chiara
AB The application of mesoporous bioactive glasses (MBGs)containing controllable amount of different ions, with the aim to impart antibacterial activity, as well as stimulation of osteogenesis and angiogenesis, is attracting an increasing interest. In this contribution, in order to endow nano-sized MBG with additional biological functions, the framework of a binary SiO2-CaO mesoporous glass was modified with different concentrations of copper ions (2 and 5% mol.), through a one-pot ultrasound-assisted sol-gel procedure. The Cucontaining MBG (2% mol.) showed high exposed surface area (550 m2 g-1), uniform mesoporous channels (2.6 nm), remarkable in vitro bioactive behaviour and sustained release of Cu2+ ions.Cu-MBG nanoparticles and their ionic dissolution extracts exhibited antibacterial effect against three different bacteria strains, E. coli, S. aureus, S. epidermidis, and the ability to inhibit and disperse the biofilm produced by S. epidermidis. The obtained results suggest that the developed material, which combines in single multifunctional agent excellent bioactivity and antimicrobial ability, offers promising opportunities for the prevention of infectious diseases and the effective treatment of bone defects.
PB Elsevier
SN 1742-7061
YR 2017
FD 2017-04-12
LK https://hdl.handle.net/20.500.14352/17838
UL https://hdl.handle.net/20.500.14352/17838
LA eng
NO Unión Europea. H2020
NO European Research Council (ERC)
DS Docta Complutense
RD 30 abr 2024