RT Journal Article
T1 Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes
A1 García-Seco Romero, María Teresa
A1 Montbrau, Carlos
A1 Fontseca, Mireia
A1 March, Ricard
A1 Sitja, Marta
A1 Domínguez Rodríguez, Lucas José
A1 Bezos Garrido, Javier
AB Salmonella enterica serovar Abortusovis (S. Abortusovis) infection is one of the most important causes of infectious late-term abortion as well as birth of weak lambs in sheep in many countries throughout the world. Implementation of protocols based on the application of effective vaccines is one of the most effective approaches for controlling this disease, but variable efficacy has been reported, possibly related to factors associated with the host, the vaccine, the parameters used for determining efficacy and the challenge protocols. In this context, a new commercial inactivated vaccine (INMEVA; Laboratorios Hipra S.A., Spain) was evaluated in 20 control and 17 vaccinated gestating ewes, subcutaneously challenged at 90 days of gestation with 5 × 106 colony-forming units (cfu) of a wild strain of S. Abortusovis. Incidence of reproductive failures, bacterial vaginal excretion (by real time PCR), and lamb survival were evaluated as indicators of the vaccine`s level of protection. Moreover, humoral response (by ELISA test in serum samples) was studied. Vaccination was showed to be safe under the study conditions. Vaccine efficacy was demonstrated in two different ways: i) it significantly decreased the percentage of abortions [29.4% (5/17) in the vaccinated group compared to the control group (65%; 13/20)] and ii) there was a significant reduction of the overall vaginal excretion in the sampling period (3.05 log cfu/mL ± 0.84 in the vaccinated group vs. 5.68 ± 0.67 in the control group).Given these results, the vaccine evaluated can be considered as an effective alternative for controlling S. Abortusovis infection in ovine flocks.
PB Elsevier
SN 0034-5288
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/123177
UL https://hdl.handle.net/20.500.14352/123177
LA eng
NO García-Seco, T., Montbrau, C., Fontseca, M., March, R., Sitja, M., Domínguez, L., & Bezos, J. (2021). Efficacy of a Salmonella enterica serovar Abortusovis (S. Abortusovis) inactivated vaccine in experimentally infected gestating ewes. Research in veterinary science, 135, 486–494. https://doi.org/10.1016/j.rvsc.2020.11.017
DS Docta Complutense
RD 27 dic 2025