RT Journal Article
T1 Drug Delivery Nanosystems for the Localized Treatment of Glioblastoma Multiforme
A1 Nam, L.
A1 Coll, C.
A1 Erthal, L.
A1 de la Torre, C.
A1 Serrano López, Dolores Remedios
A1 Martínez Máñez, R.
A1 Santos Martínez, M.
A1 Ruiz Hernández, E.
AB Glioblastoma multiforme is one of the most prevalent and malignant forms of central nervous system tumors. The treatment of glioblastoma remains a great challenge due to its location in the intracranial space and the presence of the blood–brain tumor barrier. There is an urgent need to develop novel therapy approaches for this tumor, to improve the clinical outcomes, and to reduce the rate of recurrence and adverse effects associated with present options. The formulation of therapeutic agents in nanostructures is one of the most promising approaches to treat glioblastoma due to the increased availability at the target site, and the possibility to co-deliver a range of drugs and diagnostic agents. Moreover, the local administration of nanostructures presents significant additional advantages, since it overcomes blood–brain barrier penetration issues to reach higher concentrations of therapeutic agents in the tumor area with minimal side effects. In this paper, we aim to review the attempts to develop nanostructures as local drug delivery systems able to deliver multiple agents for both therapeutic and diagnostic functions for the management of glioblastoma.
PB MDPI
SN 1996-1944
YR 2018
FD 2018-05-11
LK https://hdl.handle.net/20.500.14352/12710
UL https://hdl.handle.net/20.500.14352/12710
LA eng
NO Unión Europea. H2020
DS Docta Complutense
RD 5 abr 2025