RT Journal Article
T1 Influence of pH and concentration on the postantifungal effect and on the effects of subMIC concentrations of four antifungal agents on previously treated Candida sp
A1 García Esteban, María Teresa
A1 Llorente, María Teresa
A1 Mínguez Mínguez, Fernando A.
A1 Prieto Prieto, José
AB This study investigates the impact of different pH values (5.5 and 7.4) on the postantifungal effect (PAFE) and the effect of sub-MIC concentrations (1/4 × MIC) on C. albicans and C. glabrata in the PAFE stage (PAFSE). The PAFE stage was induced by a 1.5 h pretreatment with different doses (1, 4 and 8 × MIC) of 4 antifungal agents. An increase in the pH and/or an increase in the dose of the antimycotic prolonged the duration of the PAFE induced by amphotericin B or 5-fluorocytosine and the PAFSE induced by all 4 antifungal agents in both species. 5-Fluorocytosine and amphotericin B (except for treatment with 1 × MIC at pH 5.5) induced significant PAFEs (0.5-3.0 h and 1.4-4.8 h, respectively), which were increased (to 0.9-3.2 h and 0.8-3.4 h, respectively) by posterior (PLEASE EXPLAIN WHAT YOU MEAN BY THE WORD "POSTERIOR" HERE) exposure to 1/4 × MIC of the respective antifungal agent. Although ketoconazole and fluconazole were not able to induce significant PAFEs, posterior exposure to 1/4 × MIC of each of these 2 azoles led to significant PAFSEs of up to 2.6 h in both yeast species when the concentrations and pH were high enough.
PB Taylor & Francis
SN 0036-5548
YR 2000
FD 2000
LK https://hdl.handle.net/20.500.14352/125452
UL https://hdl.handle.net/20.500.14352/125452
LA eng
NO M. T. García, M. T. Llorente, F. Mínguez, J. Prieto. (2000). Influence of pH and Concentration on the Postantifungal Effect and on the Effects of Sub-MIC Concentrations of 4 Antifungal Agents on Previously Treated Candida spp. Scandinavian Journal of Infectious Diseases, 32(6), 669–673. https://doi.org/10.1080/003655400459603
DS Docta Complutense
RD 19 mar 2026