RT Journal Article
T1 Affinity bioelectroanalysis in cellular-level biomarker driven modern precision cancer diagnosis
A1 Campuzano Ruiz, Susana
A1 Gamella Carballo, María
A1 Pedrero Muñoz, María
A1 Pingarrón Carrazón, José Manuel
AB The increasingly prominent role played by precision, equitable and sustainable diagnosis, particularly of prevalent and highly heterogeneous diseases, based on the determination and characterization of biomarkers of cellular origin in liquid biopsy, such as whole cells, their secretomes and the exosomes they release, is unquestionable. Electrochemical biosensing and biosensors, mainly those involving affinity reactions, have emerged in recent years as competitive analytical alternatives to address these challenging targets versus other existing strategies in terms of simplicity, cost and compatibility with multiplexed or multi-omics point-of-care determinations. This review article aims to put on the table in a concise, accurate and updated way the fundamentals, versatility and opportunities provided by state-ofthe-art electrochemical biosensing (2018e2022) for the determination of these cellular-derived biomarkers. A more critical and personal view of the challenges to be faced in the shorter term and where future research and advances are expected to go is also given.
PB Elsevier
YR 2023
FD 2023-04-15
LK https://hdl.handle.net/20.500.14352/123880
UL https://hdl.handle.net/20.500.14352/123880
LA eng
NO Susana Campuzano, Maria Gamella, María Pedrero, José M. Pingarrón, Affinity bioelectroanalysis in cellular-level biomarker driven modern precision cancer diagnosis, TrAC Trends in Analytical Chemistry, Volume 163, 2023, 117064, ISSN 0165-9936, https://doi.org/10.1016/j.trac.2023.117064.
NO Ministerio de Ciencia, Innovación y Universidades
NO Comunidad de Madrid
DS Docta Complutense
RD 20 mar 2026