RT Journal Article
T1 Physical activity effects on the individual alpha peak frequency of older adults with and without genetic risk factors for Alzheimer’s Disease: A MEG study
A1 De Frutos Lucas, Jaisalmer
A1 López Sanz, David
A1 Zuluaga Arias, María Del Pilar
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Cazorla Luna, Raúl
A1 López García, María Eugenia
A1 Delgado Losada, María Luisa
A1 Marcos Dolado, Alberto
A1 Barabash Bustelo, Ana
A1 López Sánchez, Ramón
A1 Maestu Unturbe, Fernando
A1 Fernández Lucas, Alberto Amable
AB ObjectiveSince a cure for Alzheimer’s Disease (AD) is yet to be discovered, attention has shifted towards prevention. Physical activity (PA) emerged as a notorious lifestyle factor that could influence brain structure and function. The individual alpha peak frequency (IAPF) is a measure that summarizes the spectral content of brain signals and has been proven to be sensitive to both AD pathology and PA interventions. Therefore, our goal was to unravel whether chronic PA modulates IAPF and if APOE ɛ4 carriage moderates this relationship.MethodsWe analyzed 4-minutes of resting-state magnetoencephalographic recordings from 100 healthy elders that provided self-reported measures of PA, and the IAPF was calculated.ResultsWe found that IAPF was negatively influenced by age and APOE and positively influenced by PA. The effect of PA on IAPF only remained significant for the ɛ4 non-carriers group.ConclusionsPA is positively associated to higher IAPF in healthy older adults and could potentially act as a protective factor against cognitive decline. Nevertheless, such effect is non-significant among elders who are more vulnerable to developing AD due to their genetic carriage.SignificanceThis investigation offers the first neurophysiological evidences on the combined effects of APOE genotype and PA in healthy elders.
PB Elsevier
SN 1388-2457
YR 2018
FD 2018-07-09
LK https://hdl.handle.net/20.500.14352/91700
UL https://hdl.handle.net/20.500.14352/91700
LA eng
NO De Frutos-Lucas, Jaisalmer, et al. «Physical Activity Effects on the Individual Alpha Peak Frequency of Older Adults with and without Genetic Risk Factors for Alzheimer’s Disease: A MEG Study». Clinical Neurophysiology, vol. 129, n.o 9, septiembre de 2018, pp. 1981-89. DOI.org (Crossref), https://doi.org/10.1016/j.clinph.2018.06.026.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 18 jul 2024