RT Journal Article
T1 In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension
A1 Matamoros Felipe, José Antonio
A1 García Martín, Elena Salobrar
A1 Salazar Corral, Juan José
A1 López Cuenca, Inés
A1 Hurtado, Lorena Elvira
A1 Martínez López, Miguel Ángel
A1 Rubio Casado, Sara
A1 Paleo García, Víctor
A1 Hoz Montañana, María Rosa De
A1 Ramírez Sebastián, José Manuel
A1 Villa, Pedro de la
A1 Fernández Albarral, José
A1 Ramírez Sebastián, Ana Isabel
AB This study evaluated the early structural and functional effects of combined citicoline and coenzyme Q10 (CoQ10) (CitiQ10) treatment in a laser-induced ocular hypertension (OHT) model in Swiss albino mice, focusing on retinal inflammation and neuroprotection. Sixty male CD-1 mice were assigned to four groups: vehicle, CitiQ10, OHT, and OHT + CitiQ10. OHT was induced by laser photocoagulation of limbal and episcleral veins, and CitiQ10 was administered orally starting 15 days before induction. Intraocular pressure (IOP) was measured by rebound tonometry, retinal structure was assessed by spectral domain optical coherence tomography (SD-OCT), and function was evaluated using full-field electroretinography (ffERG). At 3 days post-induction, OHT eyes exhibited significant retinal nerve fiber layer (RNFL) thickening, increased vitreous particles, and early functional impairment, particularly reduced scotopic b-wave and oscillatory potentials. CitiQ10 treatment mitigated these changes, reducing vitreous particles, moderating RNFL alterations, and not exhibiting significant changes in ERG amplitudes. At 7 days post-induction, structural and functional deficits persisted but were less pronounced in treated eyes. These findings suggest that CitiQ10 treatment may attenuate early retinal damage in glaucoma, with OCT and ffERG serving as reliable monitoring tools, supporting the therapeutic potential of this approach in early stage disease.
PB MDPI
SN 1422-0067
YR 2026
FD 2026-01-20
LK https://hdl.handle.net/20.500.14352/131296
UL https://hdl.handle.net/20.500.14352/131296
LA eng
NO Matamoros, J.A.; Salobrar-García, E.; Salazar, J.J.; López-Cuenca, I.; Elvira-Hurtado, L.; Martínez, M.A.; Rubio-Casado, S.; Paleo-García, V.; Hoz, R.d.; Ramírez, J.M.; et al. In Vivo Functional and Structural Retinal Preservation by Combined Administration of Citicoline and Coenzyme Q10 in a Murine Model of Ocular Hypertension. Int. J. Mol. Sci. 2026, 27, 1012. https://doi.org/10.3390/ijms27021012
DS Docta Complutense
RD 31 ene 2026