RT Journal Article T1 Strength plus endurance training and individualized diet reduce fat mass in overweight subjects: A randomized clinical trial A1 Benito, Pedro J A1 López Plaza, Bricia A1 Bermejo López, Laura María A1 Peinado, Ana Belén A1 Cupeiro, Rocío A1 Butragueño, Javier A1 Rojo Tirado, Miguel Ángel A1 González Lamuño, Domingo A1 Gómez Candela, Carmen AB Studies with overweight people are a priority in order to observe the effect of the timing of intervention on pre-obesity people. The aim was to compare different physical activity programs plus an individualized hypocaloric diet on body composition in overweight subjects. A randomized controlled clinical trial was carried out in overweight adults with no history of relevant illness. Primary outcome was total fat mass (TFM). Participants were allocated into four activity programs with equal intensity and volume of exercise for 22 weeks: strength training (S), endurance training (E), strength + endurance training (SE), and ‘adhering to physical activity recommendations’ (C). Participants followed a diet with 25% less energy (50%-55% carbohydrates, 30%-35% fat) measured by accelerometer. Variables were assessed at baseline and at the end of the intervention. Body composition was measured by dual-energy X-ray absorptiometry. One hundred nineteen from 205 subjects were randomized in the four exercise groups (S = 30/E = 30/SE = 30/C = 29) and 84 participants (36 men/48 women) ended the intervention (S = 19/E = 25/SE = 22/C = 18). At the end of the experiment, all groups except C increased their total physical activity (S = 1159 ± 1740; E = 1625 ± 1790; SE = 1699 ± 2516; C = 724 ± 1979 MET-min/week). Using an ANOVA-test, improvements were observed in body weight (S = -4.6 ± 4.5; E = -6.6 ± 4.6; SE = -8.5 ± 2.8; C = -6.1 ± 5.6 kg, p = 0.059) and TFM (S = -4.24 ± 2.02; E = -4.74 ± 2.96; SE = -6.74 ± 3.27; C = -3.94 ± 4.18%; p < 0.05). The main conclusion was that there were no adverse events. Strength and endurance training with a balanced, individualized hypocaloric diet was the most effective at reducing weight loss and fat mass in overweight subjects. Trial registration: NCT01116856 PB MDPI YR 2020 FD 2020-04-10 LK https://hdl.handle.net/20.500.14352/114844 UL https://hdl.handle.net/20.500.14352/114844 LA eng NO Benito PJ, López-Plaza B, Bermejo LM, Peinado AB, Cupeiro R, Butragueño J, Rojo-Tirado MA, González-Lamuño D, Gómez-Candela C, On Behalf Of The Pronaf Study Group. Strength plus Endurance Training and Individualized Diet Reduce Fat Mass in Overweight Subjects: A Randomized Clinical Trial. Int J Environ Res Public Health. 2020 Apr 10;17(7):2596. NO Ministerio de Ciencia e Innovación DS Docta Complutense RD 19 abr 2025