RT Journal Article
T1 Allergy to kiwi: a double-blind, placebo-controlled food challenge study in patients from a birch-free area.
A1 Alemán, Ana
A1 Sastre, Joaquín
A1 Quirce, Santiago
A1 Heras González, Manuel De Las
A1 Carnés, Jerónimo
A1 Fernández-Caldas, Enrique
A1 Pastor Vargas, Carlos
A1 Blázquez, Ana Belén
A1 Vivanco Martínez, Fernando
A1 Cuesta-Herranz, Javier
AB ackground: Allergy to kiwi fruit is being increasingly reported, but it has never been evaluated by means of a double-blind, placebo-controlled food challenge (DBPCFC) study.Objective: We sought to assess kiwi allergy on the basis of a DBPCFC and identify the patterns of allergen recognition in sensitized patients from a birch-free area.Methods: Forty-three patients with allergy symptoms who were sensitized to kiwi were evaluated by means of clinical history, skin tests, IgE determinations, and DBPCFCs. The pattern of allergen recognition was assessed by means of IgE immunoblotting. Sequence analysis of IgE-binding bands was performed by using Edman degradation.Results: DBPCFCs were performed in 33 patients; 4 patients had experienced severe anaphylaxis, and 6 patients declined informed consent. DBPCFC results were positive in 23 patients and negative in 10 patients. The most frequent clinical manifestation was oral allergy syndrome. Twenty-one percent of the patients were not allergic to pollen. Forty-six percent of patients experienced systemic symptoms, and this happened with higher frequency in patients not allergic to pollen (100%). Twenty-eight percent of the patients were sensitized to latex. The IgE-binding bands in kiwi extract more frequently recognized by patient sera were those of 30, 24, 66, and 12 kd, and they could not be associated with any pattern of kiwi-induced allergic reactions.Conclusion: The results provide evidence that kiwi allergy is not a homogeneous disorder because several clinical subgroups can be established. No definite allergen-recognition pattern was associated with the type of allergic reactions to kiwi. One of 5 patients with kiwi allergy was not allergic to pollen, and these patients had the highest risk of systemic reactions to kiwi.
PB Elsevier
SN 0091-6749
YR 2004
FD 2004
LK https://hdl.handle.net/20.500.14352/92268
UL https://hdl.handle.net/20.500.14352/92268
LA eng
NO Alemán A, Sastre J, Quirce S, de las Heras M, Carnés J, Fernández-Caldas E, Pastor C, Blázquez AB, Vivanco F, Cuesta-Herranz J. Allergy to kiwi: a double-blind, placebo-controlled food challenge study in patients from a birch-free area. J Allergy Clin Immunol. 2004 Mar;113(3):543-50. doi: 10.1016/j.jaci.2003.11.043. PMID: 15007359.
DS Docta Complutense
RD 21 abr 2025