RT Journal Article
T1 Delayed Sensor Activation Based on Transient Coatings: Biofouling Protection in Complex Biofluids
A1 Ruiz Valdepeñas Montiel, Víctor
A1 Sempionatto, Juliane
A1 Esteban-Fernández de Ávila, Berta
A1 Whitworth, Amelia
A1 Campuzano Ruiz, Susana
A1 Pingarrón Carrazón, José Manuel
A1 Wang, Joseph
AB Transient polymeric coatings with a programmable transiency behavior are used for delayed exposure of fresh surfaces of multi-electrode sensor arrays at preselected times. Such delayed sensor actuation is shown to be extremely attractive for addressing severe biofouling characteristic of electrochemical biosensors in complex biofluids. Controlled coating dissolution and tunable sequential actuation of the individual sensing electrodes are achieved by tailoring the characteristics of the coating (density and thickness). The unique features offered by these delayed sensors allowed direct glucose monitoring in untreated blood and saliva samples over prolonged periods. This attractive delayed-sensor exposure concept, offering time-tunable sequential activation of multiple sensors with remarkable anti-biofouling properties, indicates considerable promise for operating sensors continuously in complex body fluids.
PB American Chemical Society
SN 0002-7863
YR 2018
FD 2018
LK https://hdl.handle.net/20.500.14352/95447
UL https://hdl.handle.net/20.500.14352/95447
LA eng
NO Ruiz-Valdepeñas Montiel V, Sempionatto JR, Esteban-Fernández de Ávila B, Whitworth A, Campuzano S, Pingarrón JM, Wang J. Delayed Sensor Activation Based on Transient Coatings: Biofouling Protection in Complex Biofluids. J Am Chem Soc. 2018 Oct 31;140(43):14050-14053. doi: 10.1021/jacs.8b08894. Epub 2018 Oct 19. PMID: 30336020.
NO Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense (USA)
DS Docta Complutense
RD 15 dic 2025