RT Journal Article
T1 AMPK, metabolism, and vascular function
A1 Rodríguez Prados, Claudia
A1 Muñoz Picos, Mercedes
A1 Contreras Jiménez, Cristina
A1 Prieto Ocejo, Dolores
AB Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor activated during energy stress that plays a key role in maintaining energy homeostasis. This ubiquitous signaling pathway has been implicated in multiple functions including mitochondrial biogenesis, redox regulation, cell growth and proliferation, cell autophagy and inflammation. The protective role of AMPK in cardiovascular function and the involvement of dysfunctional AMPK in the pathogenesis of cardiovascular disease have been highlighted in recent years. In this review, we summarize and discuss the role of AMPK in the regulation of blood flow in response to metabolic demand and the basis of the AMPK physiological anticontractile, antioxidant, anti-inflammatory, and antiatherogenic actions in the vascular system. Investigations by others and us have demonstrated the key role of vascular AMPK in the regulation of endothelial function, redox homeostasis, and inflammation, in addition to its protective role in the hypoxia and ischemia/reperfusion injury. The pathophysiological implications of AMPK involvement in vascular function with regard to the vascular complications of metabolic disease and the therapeutic potential of AMPK activators are also discussed
PB Wiley
SN 1742-464X
SN 1742-4658
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/126222
UL https://hdl.handle.net/20.500.14352/126222
LA eng
NO Rodríguez C, Muñoz M, Contreras C, Prieto D. AMPK, metabolism, and vascular function. The FEBS Journal [Internet]. junio de 2021 [citado 19 de noviembre de 2025];288(12):3746-71. Disponible en: https://febs.onlinelibrary.wiley.com/doi/10.1111/febs.15863
NO This work was supported by Ministerio de Ciencia e Innovación (Spain) co-funded by the FEDER Program of EU (grants nº SAF2016-77526-R and PID2019-105689RB) and Santander-Universidad Coplutense de Madrid (grant nº PR87/19-22629). Claudia Rodríguez was supported by grant FPU16/04582 from MECD (Spain).
NO Ministerio de Ciencia e Innovación (España)
NO European Commission. FEDER Program
NO Santander-Universidad Coplutense de Madrid
NO Ministerio de Educación y Formación Profesional (España)
DS Docta Complutense
RD 31 dic 2025