RT Journal Article
T1 Once bitten twice shy: Risk factors associated with bovine tuberculosis recurrence in Castilla y Leon, Spain
A1 Pozo Piñol, Pilar
A1 Bezos Garrido, Javier
A1 Romero Martínez, Beatriz
A1 Grau, Anna
A1 Nacar, Jesus
A1 Saez, Jose Luis
A1 Minguez, Olga
A1 Álvarez Sánchez, Julio
AB Persistence of bovine tuberculosis (bTB) in cattle herd remains a major challenge in disease elimination due to the ineffectual removal of all infected animals in a bTB breakdown. Characterization of herds with a higher probability of experiencing further bTB breakdowns can help to implement specific risk-based policies for disease control and eradication. Here, our aim was to identify herd- and breakdown-level risk factors in bTB infected herds in Castilla y Leon, Spain, associated with a decreased time to recurrence and an increased risk of recurrence using a mixed effects Cox proportional hazards model and a multivariable logistic regression model, respectively. Results revealed that location (province), herd size and number of incoming animals/contacts were good predictors of a decreased time to bTB recurrence and an increased risk of becoming a recurrent herd. Additionally, the duration of the previous outbreak and the number of IFN-γ herd-tests applied in it were associated with increased odds of (an early) recurrence. Risk factors identified here can be used for early identification of herds in which bTB eradication may be more challenging and that should thus be subjected to increased control efforts. The characterization of high-risk herds may help to minimize the risk of reinfection and emphasize early detection and removal of bTB positive animals in the herd.
PB Elsevier
SN 0034-5288
YR 2023
FD 2023-06
LK https://hdl.handle.net/20.500.14352/107527
UL https://hdl.handle.net/20.500.14352/107527
LA eng
NO Pozo, P., Bezos, J., Romero, B., Grau, A., Nacar, J., Saez, J. L., Minguez, O., & Alvarez, J. (2023). Once bitten twice shy: Risk factors associated with bovine tuberculosis recurrence in Castilla y Leon, Spain. Research in veterinary science, 159, 72–80. https://doi.org/10.1016/j.rvsc.2023.04.011
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Agricultura, Pesca y Alimentación (España)
NO European Union
NO Agencia Estatal de Investigacion 
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 9 abr 2025