%0 Journal Article
%A Hernandez-Rocamora, Victor
%A Maestro García-Donas, María Beatriz
%A de Waal, Bas
%A Morales, María
%A Garcia, Pedro
%A Meijer, Bert
%A Merx, Maarten
%A Sanz, Jesús
%T Multivalent Choline Dendrimers as Potent Inhibitors of Pneumococcal Cell-Wall Hydrolysis
%D 2009
%@ 1433-7851
%U https://hdl.handle.net/20.500.14352/93420.2
%X Dendritic cell-wall mimics: Choline-binding proteins from Streptococcus pneumoniae recognize distinctive multivalent choline architectures on the bacterial cell wall. Choline-functionalized dendrimers are potent inhibitors of these essential enzymes, with a 103–104-fold higher affinity than free choline, resulting in inhibition of autolysis and cell separation in bacterial cultures at low micromolar concentrations
%~