RT Journal Article
T1 Guidelines and considerations for metabolic tolerance tests in mice
A1 Benede Ubieto, Raquel
A1 Estévez Vázquez, Olga
A1 Cubero Palero, Francisco Javier
A1 Nevzorova, Yulia
AB The epidemic of the century, Diabetes Mellitus (DM) is continuously rising. Intensive research is urgently needed whereby experimental models represent an essential tool to optimise the diagnostic strategy and to improve therapy. In this review, we describe the central principles of the metabolic tests available in order to study glucose and insulin homeostasis in mice, focusing on the most widely used – the glucose and insulin tolerance tests. We provide detailed experimental procedures as well as the practical implementation of these methods and discuss the main factors that should be taken into account when using this methodology.
PB Dove Medical Press
SN 1178-7007
YR 2020
FD 2020-02-18
LK https://hdl.handle.net/20.500.14352/6234
UL https://hdl.handle.net/20.500.14352/6234
LA eng
NO Ministerio de Economía, Comercio y Empresa (España)
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
NO European Foundation for Alcohol Research
NO German Research Foundation
NO European Cooperation in Science and Technology
DS Docta Complutense
RD 5 abr 2025