RT Journal Article
T1 Elicitation from virus-naive individuals of cytotoxic T lymphocytes directed against conserved HIV-1 epitopes
A1 Reche Gallardo, Pedro Antonio
A1 Keskin, Derin B
A1 Hussey, Rebecca E
A1 Ancuta, Petronela
A1 Gabuzda, Dana
A1 Reinherz, Ellis L
AB Cytotoxic T lymphocytes (CTL) protect against viruses including HIV-1. To avoid viral escape mutants that thwart immunity, we chose 25 CTL epitopes defined in the context of natural infection with functional and/or structural constraints that maintain sequence conservation. By combining HLA binding predictions with knowledge concerning HLA allele frequencies, a metric estimating population protection coverage (PPC) was computed and epitope pools assembled. Strikingly, only a minority of immunocompetent HIV-1 infected individuals responds to pools with PPC >95%. In contrast, virus-naive individuals uniformly expand IFNgamma producing cells and mount anti-HIV-1 cytolytic activity. This disparity suggests a vaccine design paradigm shift from infected to normal subjects.
PB BioMed Central
SN 1476-9433
YR 2006
FD 2006
LK https://hdl.handle.net/20.500.14352/50380
UL https://hdl.handle.net/20.500.14352/50380
LA eng
DS Docta Complutense
RD 12 abr 2025