RT Journal Article T1 The Use of Prebiotics from Pregnancy and Its Complications: Health for Mother and Offspring—A Narrative Review A1 García Montero, Cielo A1 Fraile Martínez, Oscar A1 Rodriguez Martín, Sonia A1 Saz, Jose V. A1 Aracil Rodríguez, Rocio A1 Pina Moreno, Juan Manuel A1 Ruiz Labarta, Javier A1 García Honduvilla, Natalio A1 Álvarez Mon, Melchor A1 Bravo Arribas, Coral A1 De Leon Luis, Juan A. A1 Ortega, Miguel A. AB Pregnancy involves a metabolic reprogramming that includes changes in the gut microbiota composition in women. Evidence shows that maternal dysbiosis is linked to neonatal dysbiosis, and this factor can determine health status in adulthood. Although there is little literature available on this topic, high heterogeneity is a limitation when examining nutritional interventions. Information has been gathered to contrast the benefits of prebiotic usage, specifically in pregnancy, in its possible complications and in newborns’ gut microbiota development. The objective pursued in this brief narrative review is to provide a clear summary of relevant content when searching with regard to the use of prebiotics in pregnancy, the effects in prenatal and postnatal periods, and to help in clinical decision-making in pregnancy management and lactation. A search has found that the nutritional status of the pregnant mother is key for the earliest microbial colonization in newborns, and thus intervention programs from pregnancy could assure better outcomes in both the mother and offspring. In this sense, prebiotics (administered to mothers who breastfeed or provided in formula milk) are feasible and cost-effective elements that can prevent allergies, colic, and other maladies in newborns PB MDPI SN 2304-8158 YR 2023 FD 2023-03-08 LK https://hdl.handle.net/20.500.14352/73268 UL https://hdl.handle.net/20.500.14352/73268 LA eng NO García-Montero C, Fraile-Martinez O, Rodriguez-Martín S, Saz JV, Rodriguez RA, Moreno JMP, et al. The Use of Prebiotics from Pregnancy and Its Complications: Health for Mother and Offspring—A Narrative Review. Foods 2023;12:1148. https://doi.org/10.3390/foods12061148. NO Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainService of Pediatric, Hospital Universitario Principe de Asturias, 28801 Alcalá de Henares, SpainDepartment of Biomedicine and Biotechnology, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, SpainHealth Research Institute Gregorio Marañón, 28009 Madrid, SpainImmune System Diseases-Rheumatology and Internal Medicine Service, University Hospital Príncipe de Asturias, CIBEREHD, 28806 Alcalá de Henares, Spain NO Universidad de Alcalá: Facultad de Medicina y Ciencias de la Salud NO Instituto Ramón y Cajal de Investigación Sanitaria NO Hospital Universitario Príncipe de Asturias: Servicio de Pediatría NO Universidad Complutense de Madrid: Facultad de Medicina NO Hospital Universitario Gregorio Marañón: Obstetricia y Ginecología NO Instituto de Investigación Sanitaria Gregorio Marañón NO Hospital Universitario Príncipe de Asturias DS Docta Complutense RD 6 abr 2025