RT Journal Article
T1 Silicon-Enriched Meat Ameliorates Diabetic Dyslipidemia by Improving Cholesterol, Bile Acid Metabolism and Ileal Barrier Integrity in Rats with Late-Stage Type 2 Diabetes
A1 López-Oliva Muñoz, Mª Elvira
A1 Hernández Martín, Marina
A1 Garcimartín Álvarez, Alba
A1 Bocanegra De Juana, Aranzazu
A1 Macho González, Adrián
A1 García Fernández, Rosa Ana
A1 De Pascual Teresa, Sonia
A1 Redondo Castillejo, Rocío
A1 Bastida Codina, Sara
A1 Sánchez Muniz, Francisco José
A1 Benedí González, Juana María
A1 López-Oliva Muñoz, María Elvira
AB Silicon as a functional ingredient of restructured meat (RM) shows antidiabetic and hypocholesterolemic effects in a type 2 diabetes mellitus (T2DM) rat model. The present paper investigated the mechanisms involved in this cholesterol-lowering effect by studying the impact of silicon-RM consumption on bile acid (BA) and cholesterol metabolism. In addition, the main effects of cecal BA and short-chain fatty acids derived from the microbiota on intestinal barrier integrity were also tested. Rats were fed an RM high-saturated-fat, high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection (LD group) and for an 8 wk. period. Silicon-RM was included in the HSFHCD as a functional food (LD-Si group). An early-stage T2DM group fed a high-saturated-fat diet (ED group) was used as a reference. Silicon decreased the BA pool with a higher hydrophilic BA profile and a lower ability to digest fat and decreased the damaging effects, increasing the occludin levels and the integrity of the intestinal barrier. The ileal BA uptake and hepatic BA synthesis through CYP7A1 were reduced by FXR/FGF15 signaling activation. The silicon up-regulated the hepatic and ileal FXR and LXRα/β, improving transintestinal cholesterol (TICE), biliary BA and cholesterol effluxes. The inclusion of silicon in meat products could be used as a new therapeutic nutritional tool in the treatment of diabetic dyslipidemia.
PB MDPI
YR 2024
FD 2024-10-23
LK https://hdl.handle.net/20.500.14352/110822
UL https://hdl.handle.net/20.500.14352/110822
LA eng
NO Hernández-Martín M, Garcimartín A, Bocanegra A, Macho-González A, García-Fernández RA, de Pascual-Teresa S, Redondo-Castillejo R, Bastida S, Sánchez-Muniz FJ, Benedí J, López-Oliva ME. Silicon-Enriched Meat Ameliorates Diabetic Dyslipidemia by Improving Cholesterol, Bile Acid Metabolism and Ileal Barrier Integrity in Rats with Late-Stage Type 2 Diabetes. Int J Mol Sci. 2024 Oct 23;25(21):11405. doi: 10.3390/ijms252111405. PMID: 39518958; PMCID: PMC11547133.
NO The following supporting information can be downloaded at: https://www.mdpi.com/article/10.3390/ijms252111405/s1.
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 6 abr 2025