TY - JOUR AU - Lu, Qirong AU - Zhao, Yongxia AU - Xu, Xiaoqing AU - Guo, Pu AU - Ares Lombán, Irma AU - Martínez Caballero, Marta AU - López Torres, Bernardo AU - Martínez Larrañaga, María Rosa AU - Anadón Navarro, Arturo Ramón AU - Pan, Yuanhu AU - Wang, Xu AU - Martínez Caballero, María Aranzazu PY - 2025 DO - 10.1016/j.bcp.2025.117420 SN - 0006-2952 UR - https://hdl.handle.net/20.500.14352/125071 T2 - Biochemical Pharmacology AB - Acute lung injury (ALI) is a multi-system and multifactorial disease, which is characterised by an uncontrolled inflammatory response and high mortality. Zaltoprofen (ZPF), is a non-steroidal anti-inflammatory drug (NSAID) with powerful... LA - eng M2 - 1 PB - Elsevier Inc. KW - Acute lung injury KW - Dual target KW - Cyclooxygenase-2 KW - Peroxisome proliferator-activated receptor-γ KW - Zaltoprofen KW - Strategy TI - Zaltoprofen and its novel analogues exhibit dual targeting of COX-2 and PPAR-γ, providing a strategy to alleviate lipopolysaccharide – induced acute lung injury. TY - journal article VL - 242 ER -