RT Journal Article
T1 Cadmium-induced neurotoxic effects on rat basal forebrain cholinergic system through thyroid hormones disruption
A1 Sola Vendrell, Emma
A1 Moyano-Cires Ivanoff, Paula Viviana
A1 Flores, Andrea
A1 García Lobo, Jimena
A1 García Sánchez, José Manuel
A1 Anadón Baselga, María José
A1 Frejo Moya, María Teresa
A1 Pelayo Alarcon, Adela
A1 Fernández Fernández, María de la Cabeza
A1 Pino Sans, Javier Del
AB Cadmium (Cd) single and repeated exposure produces cognitive dysfunctions. Basal forebrain cholinergic neurons (BFCN) regulate cognitive functions. BFCN loss or cholinergic neurotransmission dysfunction leads to cognitive disabilities. Thyroid hormones (THs) maintain BFCN viability and functions, and Cd disrupts their levels. However, Cd-induced BFCN damages and THs disruption involvement was not studied. To research this we treated male Wistar rats intraperitoneally with Cd once (1 mg/kg) or repetitively for 28 days (0.1 mg/kg) with/without triiodothyronine (T3, 40 µg/kg/day). Cd increased thyroid-stimulating-hormone (TSH) and decreased T3 and tetraiodothyronine (T4). Cd altered cholinergic transmission and induced a more pronounced neurodegeneration on BFCN, mediated partially by THs reduction. Additionally, Cd antagonized muscarinic 1 receptor (M1R), overexpressed acetylcholinesterase S variant (AChE-S), downregulated AChE-R, M2R, M3R and M4R, and reduced AChE and choline acetyltransferase activities through THs disruption. These results may assist to discover cadmium mechanisms that induce cognitive disabilities, revealing a new possible therapeutic tool.
PB Elsevier
SN 1382-6689
YR 2021
FD 2021-12-28
LK https://hdl.handle.net/20.500.14352/72464
UL https://hdl.handle.net/20.500.14352/72464
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Universidad Complutense de Madrid/Banco de Santander
DS Docta Complutense
RD 30 abr 2024