RT Journal Article
T1 Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment.
A1 Colilla Nieto, Montserrat
A1 Vallet Regí, María Dulce Nombre
AB The rise of antibiotic resistance and the growing number of biofilm-related infectionsmake bacterial infections a serious threat f or global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infectiontargeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.
PB MDPI
SN 1422-0067
YR 2020
FD 2020-11-15
LK https://hdl.handle.net/20.500.14352/7526
UL https://hdl.handle.net/20.500.14352/7526
LA eng
NO RESEARCHER ID N-4628-2014 (Montse Colilla Nieto)ORCID 0000-0003-1961-4160  (Montse Colilla Nieto)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 30 abr 2024