%0 Journal Article
%A Patino Alonso, Jennifer
%A Cabrera González, Justo Enrique
%A Merino Gracia, Javier
%A Nieta-Ortiz, Gema
%A Katati, Jouma
%A Bezerra da Cruz, Carlos
%A Mateos Gil, Pablo
%A Canales Mayordomo, María Ángeles
%A López Montero, Iván
%A Illescas Martínez, Beatriz María
%A Delgado Vázquez, Rafael
%A Martín León, Nazario
%T C60-based Multivalent Glycoporphyrins Inhibit SARS-CoV-2 Specific Interaction with the DC-SIGN Transmembrane Receptor
%D 2023
%@ 1613-6810
%U https://hdl.handle.net/20.500.14352/98371
%X Since WHO has declared the COVID-19 outbreak a global pandemic, nearly seven million deaths have been reported. This efficient spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is facilitated by the ability of the spike glycoprotein to bind multiple cell membrane receptors. Although ACE2 is identified as the main receptor for SARS-CoV-2, other receptors could play a role in viral entry. Among others, C-type lectins such as DC-SIGN are identified as efficient trans-receptor for SARS-CoV-2 infection, so the use of glycomimetics to inhibit the infection through the DC-SIGN blockade is an encouraging approach. In this regard, multivalent nanostructures based on glycosylated [60]fullerenes linked to a central porphyrin scaffold have been designed and tested against DC-SIGN-mediated SARS-CoV-2 infection. First results show an outstanding inhibition of the trans-infection up to 90%. In addition, a deeper understanding of nanostructure-receptor binding is achieved through microscopy techniques, high-resolution NMR experiments, Quartz Crystal Microbalance experiments, and molecular dynamic simulations.
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