RT Journal Article
T1 Dementia-associated mortality at thirteen years in the NEDICES Cohort Study
A1 Villarejo Galende, Alberto
A1 Benito León, Julián
A1 Trincado, Rocío
A1 Posada Rodríguez, Ignacio Javier
A1 Puertas Martín, V
A1 Boix, R
A1 Medrano, María R
A1 Bermejo Pareja, Félix
AB To evaluate the mortality, thirteen years after the baseline wave (1994), of participants suffering dementia in the Neurological Disorders in Central Spain (NEDICES) Cohort Study, we conducted a population-based cohort study in the elderly (65 years and more) with 5,278 screened participants at baseline. Mortality has been evaluated by means of the National Death Registry of Spain at 1-5-2007, 13 years after enrolment. Cox's proportional hazards regression models were used to evaluate the hazard of death according to dementia severity and type, adjusting for potential covariates (gender, age, level of education, and co-morbidity). Survival was estimated using Kaplan-Meier method. Of the 5,278 participants screened at baseline, 306 had dementia. Mortality at 13 years was: 275 deaths (89.9%) in dementia subjects; and 2,426 (49.0%) in subjects without dementia. Mortality was higher and statistically significant in dementia subjects. The degree of dementia (DSM-III-R) correlated with the risk of mortality, from mild (HR = 2.23; CI: 1.77–2.82) to moderate (HR =3.10; CI: 2.47–3.89) and severe dementia (HR = 4.98; CI: 3.85–6.44). Survival was similar in Alzheimer's disease and vascular dementia. Factors associated with higher mortality in Cox proportional hazard models were older age, male gender, and comorbidity. Using Population Attributable risk (PAR%), dementia was related to 11.3% of all deaths. Dementia intensity increases the mortality risk at ten years in the NEDICES Study as in other cohort studies. Age, gender, and co-morbidity are associated with higher mortality in dementia patients. Almost one third of deaths in persons over 85 years-old could be attributable to dementia.
PB SAGE Publications
SN 1387-2877
YR 2011
FD 2011-04-28
LK https://hdl.handle.net/20.500.14352/117601
UL https://hdl.handle.net/20.500.14352/117601
LA eng
NO 1. Villarejo A, Benito-León J, Trincado R, et al. Dementia-Associated Mortality at Thirteen Years in the NEDICES Cohort Study. Journal of Alzheimer’s Disease. 2011;26(3):543-551. doi:10.3233/JAD-2011-110443
NO Fundación Mutua Madrileña
NO Instituto de Salud Carlos III
NO Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas
DS Docta Complutense
RD 19 abr 2025