RT Journal Article
T1 Synthesis, characterization and biocompatibility of mesolamellar calcium phosphate hybrids prepared via anionic surfactant templating
A1 Salinas Sánchez, Antonio Jesús
A1 Blanco Bécares, José M.
A1 Mersinlioglu, Okan
A1 Casarrubios Molina, Laura
A1 Fernández Villa, Daniel
A1 Feito Castellano, María José
A1 Portolés Pérez, María Teresa
A1 González Ortiz, Blanca
A1 Vallet Regí, María Dulce Nombre
AB Calcium phosphate (CaP) based hybrid materials have been synthesized through a precipitation method in aqueous medium in the presence of the anionic surfactant sodium dodecylbenzene sulfonate (SDBS) as structure directing agent. Parameters of synthesis, such as Ca/P molar ratio, surfactant concentration and initial pH, have been investigated trying to get mesostructured CaP phases. A lamellar-like hybrid mesophase consisting in several wavy layers of apatite or apatite-brushite nanoplates was successfully obtained. Materials have been characterized by several physico- chemical techniques. A potential application of these lamellar calcium phosphate based hybrids can be as matrixes in drug delivery systems with the possibility of loading hydrophobic drugs in the organic interlayers. To evaluate their potential as biomaterials, the biocompatibility of two hybrids has been studied in vitro with human Saos-2 osteoblasts. Cell assays showed that, upon the appropriate synthesis and stabilization conditions, a biocompatible CaP and SDBS mesolamellar hybrid can be prepared.
PB Wiley Online Library
SN 2365-6549
YR 2018
FD 2018-05-25
LK https://hdl.handle.net/20.500.14352/12183
UL https://hdl.handle.net/20.500.14352/12183
LA eng
NO Salinas Sánchez, A. J., Blanco Bécares, J. M., Mesinlioglu, O. et al. «Synthesis, Characterization and Biocompatibility of Mesolamellar Calcium Phosphate Hybrids Prepared by Anionic Surfactant Templating». ChemistrySelect, vol. 3, n.o 24, junio de 2018, pp. 6880-91. DOI.org (Crossref), https://doi.org/10.1002/slct.201703130.
NO RESEARCHER ID M-3316-2014 (Antonio Salinas Sánchez)ORCID 0000-0002-8408-3389 (Antonio Salinas Sánchez)RESEARCHER ID U-1678-2017 (María Teresa Portolés Pérez)ORCID 0000-0002-9681-0184 (María Teresa Portolés Pérez)RESEARCHER ID K-4773-2015 (Blanca González Ortiz)ORCID 0000-0002-0493-6071 (Blanca González Ortiz)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
DS Docta Complutense
RD 4 abr 2025