%0 Journal Article
%A Moraga Yébenes, Ana
%A Gómez Vallejo, Vanessa
%A Cuartero Desviat, María Isabel
%A Szczupak, Boguslaw
%A San Sebastián, Eneko
%A Markuerkiaga, Irati
%A Pradillo Justo, Jesús Miguel
%A Higuchi, Makoto
%A Llop, Jordi
%A Moro Sánchez, María Ángeles
%A Martín, Abraham
%A Lizasoaín Hernández, Ignacio
%T Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography
%D 2016
%@ 0271-678X
%@ 1559-7016
%U https://hdl.handle.net/20.500.14352/95797
%X The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+)and TLR4(-/-)mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-)mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
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