RT Journal Article
T1 Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography
A1 Moraga Yébenes, Ana
A1 Gómez Vallejo, Vanessa
A1 Cuartero Desviat, María Isabel
A1 Szczupak, Boguslaw
A1 San Sebastián, Eneko
A1 Markuerkiaga, Irati
A1 Pradillo Justo, Jesús Miguel
A1 Higuchi, Makoto
A1 Llop, Jordi
A1 Moro Sánchez, María Ángeles
A1 Martín, Abraham
A1 Lizasoaín Hernández, Ignacio
AB The influence of toll-like receptor 4 on neurogenesis and inflammation has been scarcely explored so far by using neuroimaging techniques. For this purpose, we performed magnetic resonance imaging and positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 at 2, 7, and 14 days following cerebral ischemia in TLR4(+/+)and TLR4(-/-)mice. MRI showed similar infarction volumes in both groups. Despite this, positron emission tomography with 3'-deoxy-3'-[(18)F]fluorothymidine and [(11)C]PK11195 evidenced an increase of neurogenesis and a decrease of inflammation in TLR4(-/-)mice after ischemia. These results evidence the versatility of neuroimaging techniques to monitor the role of toll-like receptor 4 after cerebral ischemia.
PB SAGE Publications
SN 0271-678X
SN 1559-7016
YR 2016
FD 2016-01-19
LK https://hdl.handle.net/20.500.14352/95797
UL https://hdl.handle.net/20.500.14352/95797
LA eng
NO Moraga A, Gómez-Vallejo V, Cuartero MI, Szczupak B, San Sebastián E, Markuerkiaga I, Pradillo JM, Higuchi M, Llop J, Moro MÁ, Martín A, Lizasoain I. Imaging the role of toll-like receptor 4 on cell proliferation and inflammation after cerebral ischemia by positron emission tomography. J Cereb Blood Flow Metab. 2016 Apr;36(4):702-8. doi: 10.1177/0271678X15627657
DS Docta Complutense
RD 12 abr 2025