%0 Journal Article
%A Fernández Aceñero, María Jesús
%A Martinez Useros, J
%A Díez Valladares, Luis Ignacio
%A García Botella, Alejandra María
%A Ortega Medina, Luis
%A Pérez Aguirre, María Elia
%A De la-Serna Esteban, Sofía Cristina
%A Latorre, E
%A Neelsen, L
%T Still a place for conventional histopathological analysis in the era of molecular medicine: predicting prognosis of resectable ductal pancreatic adenocarcinoma
%D 2019
%@ 1699-048X
%U https://hdl.handle.net/20.500.14352/130078
%X IntroductionOur aim is to find features that define prognosis in surgically resected ductal pancreatic adenocarcinoma readily accessible in everyday practice.Materials and methodsLongitudinal retrospective case series of pancreatic adenocarcinoma operated with a curative intent in a large tertiary hospital in Madrid between 2009 and 2015.Results162 were enrolled. 40.8% survived less than 1year. Multivariate Cox's regression model revealed that gender, presence of symptoms, T and N stage independently influenced progression-free survival, while overall survival was determined by gender, smoking, presence of symptoms and N stage. Logistic regression analysis revealed that only symptoms at diagnosis could predict death, while gender, symptoms, histopathological type, vessel invasion, T stage and necrosis could independently predict recurrence.DiscussionOur series show that patients with symptomatic disease at the time of diagnosis and females showed a shorter progression-free and overall survival. We herein propose a regression model to predict outcome.
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