RT Journal Article
T1 Still a place for conventional histopathological analysis in the era of molecular medicine: predicting prognosis of resectable ductal pancreatic adenocarcinoma
A1 Fernández Aceñero, María Jesús
A1 Martinez Useros, J
A1 Díez Valladares, Luis Ignacio
A1 García Botella, Alejandra María
A1 Ortega Medina, Luis
A1 Pérez Aguirre, María Elia
A1 De la-Serna Esteban, Sofía Cristina
A1 Latorre, E
A1 Neelsen, L
AB IntroductionOur aim is to find features that define prognosis in surgically resected ductal pancreatic adenocarcinoma readily accessible in everyday practice.Materials and methodsLongitudinal retrospective case series of pancreatic adenocarcinoma operated with a curative intent in a large tertiary hospital in Madrid between 2009 and 2015.Results162 were enrolled. 40.8% survived less than 1year. Multivariate Cox's regression model revealed that gender, presence of symptoms, T and N stage independently influenced progression-free survival, while overall survival was determined by gender, smoking, presence of symptoms and N stage. Logistic regression analysis revealed that only symptoms at diagnosis could predict death, while gender, symptoms, histopathological type, vessel invasion, T stage and necrosis could independently predict recurrence.DiscussionOur series show that patients with symptomatic disease at the time of diagnosis and females showed a shorter progression-free and overall survival. We herein propose a regression model to predict outcome.
PB SPRINGER
SN 1699-048X
YR 2019
FD 2019-06-24
LK https://hdl.handle.net/20.500.14352/130078
UL https://hdl.handle.net/20.500.14352/130078
LA eng
DS Docta Complutense
RD 13 ene 2026