RT Journal Article
T1 Pharmacokinetic behaviour of enrofloxacin in greater rheas following a single-dose intramuscular administration
A1 Lucas Burneo, José Julio De
A1 Navarro, J. L.,
A1 Rubio Langre, Sonia
A1 Vignolo, P. E.
A1 Asis, V. C.
A1 González Gómez, Fernando
A1 Rodríguez Fernández, Casilda
AB The pharmacokinetic behaviour of enrofloxacin in greater rheas was investigated after intramuscular (IM) administration of 15 mg/kg. Plasma concentrations of enrofloxacin and its active metabolite, ciprofloxacin, were determined by high performance liquid chromatography. Enrofloxacin peak plasma concentration (Cmax = 3.30 ± 0.90 μg/mL) was reached at 24.17 ± 9.17 min. The terminal half-life (t1/2λ) and area under the curve (AUC) were 2.85 ± 0.54 h and 4.18 ± 0.69 μg h/mL, respectively. The AUC and Cmax for ciprofloxacin were 0.25 ± 0.06 μg/mL and 0.66 ± 0.16 μg h/mL, respectively. Taking into account the values obtained for the efficacy indices, an IM dose of 15 mg/kg of enrofloxacin would appear to be adequate for treating infections caused by highly susceptible bacteria (MIC90 < 0.03 μg/mL) in greater rheas.
PB Elsevier
SN 1090-0233
YR 2008
FD 2008
LK https://hdl.handle.net/20.500.14352/112368
UL https://hdl.handle.net/20.500.14352/112368
LA eng
NO de Lucas, J. J., Navarro, J. L., Rubio, S., Vignolo, P. E., Asis, V. C., González, F., & Rodríguez, C. (2008). Pharmacokinetic behaviour of enrofloxacin in greater rheas following a single-dose intramuscular administration. Veterinary journal (London, England : 1997), 175(1), 136–138. https://doi.org/10.1016/j.tvjl.2006.11.007
DS Docta Complutense
RD 9 abr 2025