RT Journal Article T1 Advancing rhodium nanoparticle-based photodynamic cancer therapy: quantitative proteomics and in vivo assessment reveal mechanisms targeting tumor metabolism, progression and drug resistance A1 Machuca Marcos, Andrés A1 Peñalver, Gabriel A. A1 Álvarez-Fernández García, Roberto A1 Martínez López, Angélica A1 Castillo Lluva, Sonia A1 García Calvo, Estefanía A1 Luque García, José Luis AB Rhodium nanoparticles have been recently discovered as good photosensitizers with great potential in cancer photodynamic therapy by effectively inducing cytotoxicity in cancer cells under near-infrared laser. This study evaluates the molecular mechanisms underlying such antitumoral effect through quantitative proteomics. The results revealed that rhodium nanoparticle-based photodynamic therapy disrupts tumor metabolism by downregulating key proteins involved in ATP synthesis and mitochondrial function, leading to compromised energy production. The treatment also induces oxidative stress and apoptosis while targeting the invasion capacity of cancer cells. Additionally, key proteins involved in drug resistance are also affected, demonstrating the efficacy of the treatment in a multi-drug resistant cell line. In vivo evaluation using a chicken embryo model also confirmed the effectiveness of the proposed therapy in reducing tumor growth without affecting embryo viability. YR 2024 FD 2024-10-20 LK https://hdl.handle.net/20.500.14352/120467 UL https://hdl.handle.net/20.500.14352/120467 LA eng NO Machuca, Andres, et al. «Advancing Rhodium Nanoparticle-Based Photodynamic Cancer Therapy: Quantitative Proteomics and in Vivo Assessment Reveal Mechanisms Targeting Tumor Metabolism, Progression and Drug Resistance». Journal of Materials Chemistry B, vol. 12, n.o 46, 2024, pp. 12073-86. DOI.org (Crossref), https://doi.org/10.1039/D4TB01631A. NO Ministerio de Ciencia e Innovación NO Universidad Complutense de Madrid DS Docta Complutense RD 8 jun 2025