%0 Journal Article
%A de Mingo, Marta
%A Morán, Alberto
%A Sánchez Pernaute, Andrés
%A Iniesta Serrano, María Pilar
%A Díez Valladares, Luis Ignacio
%A Pérez Aguirre, María Elia
%A Juan Chocano, María Del Carmen De
%A Garcia Aranda,  Cristina
%A Díaz López, Antonio
%A García Botella, Alejandra María
%A Martín Antona, Esteban
%A Benito De Las Heras, Manuel R.
%A Torres García, Antonio José
%A Balibrea Cantero, José Luis
%T Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma
%D 2007
%@ 0172-6390
%U https://hdl.handle.net/20.500.14352/130076
%X Background/Aims: The aim of the present work is to clarify the role of metalloproteinase-9 and its inhibitor in the evolution of gastric cancer after surgical resection.Methodology: We have studied 44 gastric cancer patients submitted to surgery. There were 13 proximal tumors, 16 located in the middle third and 15 in the distal one. Overall survival was 26% at 6 years. Metalloproteinase-9 and tissue inhibitor of metalloproteinase concentrations were investigated by means of ELISA in frozen samples of tumoral and normal gastric mucosa.Results: Mean concentration of metalloproteinase-9 in tumoral tissue was 42ng/mg of total protein, and this value was 6.9 times greater than the mean concentration in non-tumoral tissue. Cancer tissue also expressed higher levels of TIMP-1, 7.25 versus 4.39ng/mg of protein. Higher levels of metalloproteinase expression in tumoral tissue, greater [metalloproteinase in tumor]/[metalloprotoinase in nontumor] ratio and greater [metalloproteinase]/Einhibitorl ratio in tumor cells, were all of them statistically related to a worse prognosis when T1 and T2 tumors were considered.Conclusions: The expression of metalloproteinase9 or its inhibitor is related to a more aggressive phenotype of gastric cancer.
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