RT Journal Article
T1 Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma
A1 de Mingo, Marta
A1 Morán, Alberto
A1 Sánchez Pernaute, Andrés
A1 Iniesta Serrano, María Pilar
A1 Díez Valladares, Luis Ignacio
A1 Pérez Aguirre, María Elia
A1 Juan Chocano, María Del Carmen De
A1 Garcia Aranda, Cristina
A1 Díaz López, Antonio
A1 García Botella, Alejandra María
A1 Martín Antona, Esteban
A1 Benito De Las Heras, Manuel R.
A1 Torres García, Antonio José
A1 Balibrea Cantero, José Luis
AB Background/Aims: The aim of the present work is to clarify the role of metalloproteinase-9 and its inhibitor in the evolution of gastric cancer after surgical resection.Methodology: We have studied 44 gastric cancer patients submitted to surgery. There were 13 proximal tumors, 16 located in the middle third and 15 in the distal one. Overall survival was 26% at 6 years. Metalloproteinase-9 and tissue inhibitor of metalloproteinase concentrations were investigated by means of ELISA in frozen samples of tumoral and normal gastric mucosa.Results: Mean concentration of metalloproteinase-9 in tumoral tissue was 42ng/mg of total protein, and this value was 6.9 times greater than the mean concentration in non-tumoral tissue. Cancer tissue also expressed higher levels of TIMP-1, 7.25 versus 4.39ng/mg of protein. Higher levels of metalloproteinase expression in tumoral tissue, greater [metalloproteinase in tumor]/[metalloprotoinase in nontumor] ratio and greater [metalloproteinase]/Einhibitorl ratio in tumor cells, were all of them statistically related to a worse prognosis when T1 and T2 tumors were considered.Conclusions: The expression of metalloproteinase9 or its inhibitor is related to a more aggressive phenotype of gastric cancer.
PB H.G.E. Update Medical Publishing Ltd.
SN 0172-6390
YR 2007
FD 2007-01-01
LK https://hdl.handle.net/20.500.14352/130076
UL https://hdl.handle.net/20.500.14352/130076
LA eng
NO de Mingo M, Morán A, Sánchez-Pernaute A, Iniesta P, Díez-Valladares L, Pérez-Aguirre E, et al. Expression of MMP-9 and TIMP-1 as prognostic markers in gastric carcinoma. Hepatogastroenterology 2007;54:315–9.
DS Docta Complutense
RD 14 ene 2026