RT Journal Article
T1 Negative Prognostic Impact of the Coexpression of Epidermal Growth Factor Receptor and c-erbB-2 in Locally Advanced Cervical Cancer
A1 Pérez-Regadera Gómez, José Fermín
A1 Sánchez-Muñoz, Alfonso
A1 De-la-Cruz, Javier
A1 Ballestín Carcavilla, Claudio
A1 Lora Pablos, David
A1 García-Martín, Rosa
A1 Mendiola Fernández, Dionisio César
A1 Alonso, Lorenzo
A1 Alba, Emilio
A1 Lanzós González, Eduardo
AB Objective: The objective was to determine the impact of the coexpression of epidermal growth factor receptor (EGFR) and tumor marker c-erbB-2 on disease-free survival (DFS) and pelvic relapse-free survival (PRFS) in patients with locally advanced cervical cancer (LACC) receiving concurrent chemoradiotherapy.Methods: The expression of EGFR and c-erbB-2 was assessed by immunohistochemistry, which was centralized and blinded to outcome. Univariate and multivariate analyses were used to evaluate the impact of EGFR and c-erbB-2 on DFS and PRFS.Results: 170 patients with LACC were included and received concurrent chemoradiotherapy. 25 (15%) biopsies were considered EGFR and c-erbB-2 positive; 100 (59%) were either EGFR or c-erbB-2 positive, and 45 (26%) were EGFR and c-erbB-2 negative. The 3- and 5-year DFS was 39% each for EGFR- and c-erbB-2-positive patients, 54 and 49%, respectively, for EGFR- or c-erbB-2-positive patients, and 76 and 72%, respectively, for EGFR- and c-erbB-2-negative patients (p = 0.006). EGFR- and c-erbB-2-positive tumors were significantly associated with a decrease in PRFS (hazard ratio, HR, 3.99; 95% confidence interval, CI, 1.44-11.05, p = 0.007), and DFS (HR 2.9; 95% CI, 1.26-6.66, p = 0.01).Conclusion: Patients with LACC coexpressing EGFR and c-erbB-2, and treated with concurrent chemoradiotherapy, had a worse clinical prognosis with shorter DFS and PRFS.
PB Karger
SN 0030-2414
SN 1423-0232
YR 2009
FD 2009
LK https://hdl.handle.net/20.500.14352/116118
UL https://hdl.handle.net/20.500.14352/116118
LA eng
NO Pérez-Regadera J, Sánchez-Muñoz A, De-la-Cruz J, Ballestín C, Lora D, García-Martín R, Mendiola C, Alonso L, Alba E, Lanzós E. Negative prognostic impact of the coexpression of epidermal growth factor receptor and c-erbB-2 in locally advanced cervical cancer. Oncology. 2009;76(2):133-41. doi: 10.1159/000195539. Epub 2009 Jan 28. PMID: 19174612.
DS Docta Complutense
RD 17 dic 2025