%0 Journal Article
%A Salazar Roa, María
%A Carracedo, Arkaitz
%A Salanueva, Íñigo 
%A Hernández Tiedra, Sonia
%A Egia, Ainara
%A Lorente Pérez, María Del Mar
%A Vázquez, Patricia
%A Torres, Sofia
%A Iovanna, Juan 
%A Guzmán Pastor, Manuel
%A Boya, Patricia
%A Velasco Díez, Guillermo
%T TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action
%D 2009
%@ 1554-8627
%U https://hdl.handle.net/20.500.14352/97786
%X Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo.
%~