RT Journal Article
T1 TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action
A1 Salazar Roa, María
A1 Carracedo, Arkaitz
A1 Salanueva, Íñigo
A1 Hernández Tiedra, Sonia
A1 Egia, Ainara
A1 Lorente Pérez, María Del Mar
A1 Vázquez, Patricia
A1 Torres, Sofia
A1 Iovanna, Juan
A1 Guzmán Pastor, Manuel
A1 Boya, Patricia
A1 Velasco Díez, Guillermo
AB Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, is being investigated as a potential anti-tumoral agent. We find that THC stimulates an endoplasmic reticulum (ER) stress-related signaling pathway, which activates autophagy via inhibition of the Akt/mTORC1 axis. We also show that autophagy is upstream of apoptosis in cannabinoid-induced cancer cell death and that activation of this pathway is necessary for the anti-tumoral action of cannabinoids in vivo.
PB Taylor & Francis 
SN 1554-8627
YR 2009
FD 2009
LK https://hdl.handle.net/20.500.14352/97786
UL https://hdl.handle.net/20.500.14352/97786
LA eng
NO Salazar, M., Carracedo, A., Salanueva, Í. J., Hernández-Tiedra, S., Egia, A., Lorente, M., … Velasco, G. (2009). TRB3 links ER stress to autophagy in cannabinoid antitumoral action. Autophagy, 5(7), 1048–1049. https://doi.org/10.4161/auto.5.7.9508
DS Docta Complutense
RD 20 abr 2025