TY - JOUR AU - Zhao, Min AU - Rodríguez Villagra, Esther AU - Kowalczuk, Laura AU - Le Normand, Manon AU - Berdugo, Marianne AU - Levy-Boukris, Rinath AU - El Zaoui, Ikram AU - Kaufmann, Béatrice AU - Gurny, Robert AU - Bravo Osuna, Irene AU - Molina Martínez, Irene Teresa AU - Herrero Vanrell, María Del Rocío AU - Behar-Cohen, Francine PY - 2017 DO - 10.1016/j.jconrel.2017.09.029 SN - 0168-3659 UR - https://hdl.handle.net/20.500.14352/18741 T2 - Journal of Controlled Release AB - Mineralocorticoid receptor (MR)contributes to retinal/choroidal homeostasis. Excess MR activation has been shown to be involved in pathogenesis of central serous chorioretinopathy (CSCR). Systemic administration of MR antagonist (MRA) reduces... LA - eng M2 - 187 PB - Elsevier KW - Mineralocorticoid receptor KW - Spironolactone KW - Microspheres intraocular tolerance KW - Poly lactic-co-glycolic acid (PLGA) KW - In vivo electroretinography KW - In vivo optical coherence tomography KW - Immunohistochemistry TI - Tolerance of high and low amounts of PLGA microspheres loaded with mineralocorticoid receptor antagonist in retinal target site TY - journal article VL - 266 ER -